Giant cell tumour (GCT) of the distal radius is an uncommon benign but locally aggressive bone neoplasm that poses a surgical challenge due to its anatomical location and potential for joint destruction. Its management in advanced stages, such as Campanacci grade III, often requires en bloc resection followed by structural reconstruction to restore function and stability. We report the case of a 36-year-old woman diagnosed with a Campanacci III GCT of the distal radius. The patient underwent en bloc tumour resection followed by reconstruction using a structural allograft and dynamic compression plate fixation. Additionally, an ulnar osteotomy and screw fixation were performed to stabilize the distal radioulnar joint. Postoperative radiographs confirmed appropriate graft-host integration. Clinically, the patient experienced mild, non-disabling pain and preserved wrist range of motion and distal radioulnar joint stability during follow-up. This case highlights the efficacy of using structural allografts in the management of advanced GCT of the distal radius. This approach allows for joint preservation, functional recovery, pain control, and avoids donor site morbidity associated with autografts. Although infrequent, such tumours require individualized, multidisciplinary management supported by detailed surgical planning.
Keywords: Giant cell tumour, Distal radius, En bloc resection, Structural allograft, Orthopaedic oncology, Bone reconstruction.