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Role of platelet rich plasma in patients of osteoarthritis knee-a prospective study

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Original Article

Author Details : Farid Mohammed, Varun Aggarwal, Sudhir S. Kushwaha, Amit Verma, Yasir Ali Khan

Volume : 3, Issue : 2, Year : 2017

Article Page : 171-175

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Abstract

Introduction: In the present study, we evaluated the effects of 2 courses of PRP injections with 3 weeks interval, on patient's quality of life and functional ability.
Materials and Method: It was a prospective study carried out on 55 patients (14 males & 41 females) in the Department of Orthopedics’, Era’s Lucknow Medical College, Lucknow, and Uttar Pradesh from Sep 2015 to March 2016. Age >40 years, Knee arthralgia (>3 months) and Radiologic evidence of articular damage (grades 1-3 of Kellgren-Lawrence scale) based on knee Osteoarthritis criteria of American College of Rheumatology were enrolled in our study. Two intra-articular injections of Platelet Rich Plasma (PRP) at 3 weeks interval was given and patient was regularly followed up after 3^rd week, 6^th week, 3 months & 6 months of the 1^st injection
Results: Mean scores of all WOMAC parameters improved significantly compared to before treatment. Each Parameter of the WOMAC Score was compared with baseline score at each follow-up. Reduction in the mean pain, mean physical function and mean total womac scores from base line scores were observed during the course of 1^st (3 weeks) &2^nd (6 weeks) follow-ups then after marginal increase in scores were reported during 3^rd (3 months) and 4^th (6 months)follow ups but difference in mean of all scores were significant with the respective base line scores.
Conclusion: The results of our study showed that intra-articular knee injections of Autologous Platelet Rich Plasma (PRP) are effective in reducing joint pain, stiffness and improve knee functions in early knee Osteoarthritis.

Keywords: Platelet Rich Plasma, Knee Osteoarthritis

How to cite : Mohammed F, Aggarwal V, Kushwaha S S, Verma A, Khan Y A, Role of platelet rich plasma in patients of osteoarthritis knee-a prospective study. Indian J Orthop Surg 2017;3(2):171-175

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